The University of Indonesia (UI) and IPB Research Team found a compound that could possibly be a corona antivirus from Indonesian natural ingredients. These compounds include hesperidin, rhamnetin, kaempferol, quercetin and myricetin contained in guava (pink fruit flesh), orange peel, and moringa leaves. FKUI Dean Ari Fahrial Syam explained the research was based on screening results of hundreds of proteins and thousands of herbal compounds related to the mechanism of action of the virus. It turned out to be obtained by several classes of compounds that have the potential to inhibit and prevent the SARS-CoV-2 virus (corona virus).
"A combination of multidisciplinary researchers conducted a big data analysis and machine learning from the HerbalDB database developed by the Biomedical Computing Laboratory and Drug Design of the Faculty of Pharmacy UI totaling 1,377 herbal compounds," Ari said in a press release on Friday (3/13).
Ari explained that pharmacophore mapping was carried out using the structure and ligand method. Then the results were confirmed using molecular modeling methods to evaluate their antiviral activity. "The results of this discovery are expected to be beneficial for the community to prevent and increase endurance from the corona virus attack," Ari said. 165 milligrams (mg) of vitamin C. Meanwhile, one orange contains only 69 mg, the content of vitamin C in guava is effective in treating male infertility.
Under its green skin, guava has many benefits offered. One guava fruit a day is useful to reduce the risk of diseases ranging from the common cold, swollen gums, high blood pressure, obesity, diabetes to cancer. Guava has abundant dietary fiber so it is good for those who suffer from constipation. For those who are trying to lose weight, the high content of guava fiber is also very beneficial. This fruit is rich in vitamins, fiber and minerals. If used as part of daily food, research shows guava is very effective in preventing cancer and heart disease. The fruit, which has the Latin name Psidium guajava, helps the body fight free radicals produced during metabolism. Researchers working for the United States Department of Agriculture (USDA) have found that guava is probably among the richest fruits of antioxidants. This delicious fruit also has beta carotene, potassium and soluble fiber. Guava can improve heart health by controlling blood pressure and cholesterol. Guava's ability to reduce blood pressure is due to the presence of potassium. Potassium is an electrolyte that is important for electrical reactions in the body including the heart. This fruit is also known to heal external wounds and treat nose and gum bleeding. The fruit that lives in the tropics can also prevent diseases of 'old people' such as senile dementia and cataracts. The presence of complex carbohydrates and high fiber content can be useful for reducing cholesterol and blood sugar levels. Eating a guava for breakfast provides a much needed daily dose such as iron, folic acid, calcium, fiber, protein, carbohydrates, vitamins A, B and lots of vitamin C. The total fat content of one guava is around 0.9 gram or 84 calories . Compared to apples, this fruit has 38 percent fat and 42 percent fewer calories.
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